Updated by the Progyny Editorial Team — December 2025.
Choosing a sperm donor is a deeply personal decision. With so many factors to consider, it can feel overwhelming, but the right information can help you make a choice that fits your family-building goals.
Key factors to consider
Genetic health
If you’ve had genetic testing and are a carrier for a specific mutation, select a donor who has tested negative for that same condition. This helps reduce the risk of passing genetic diseases to your child.
Cytomegalovirus (CMV) status
CMV is a common virus. If you’ve never been exposed, choose a donor who is also CMV negative to lower the risk of complications during pregnancy.
Blood type and Rhesus factor (Rh)
Blood type may be relevant, especially if you or your partner are Rh negative. Rh is a protein found on the surface of red blood cells. Matching Rh factor can help prevent immune-related complications in pregnancy.
Family planning needs
Sperm banks limit how many vials can be sold per donor. Consider purchasing multiple vials if you anticipate multiple pregnancy attempts or if you want to use the same donor for future siblings.
Learning about the donor
Many sperm banks offer membership options that give access to:
- Photos of the donor as a child and/or adult
- Audio interviews to learn about the donor’s personality, values, and life experiences
- Medical and family history for several generations
These resources can help you feel confident in your choice by providing a fuller picture of who the donor is.
Support for your decision
While choosing a donor can feel daunting, your care team and the information provided by sperm banks can guide you. Many banks also offer matching services to help you find a donor who aligns with your preferences and goals.
If you have questions, Progyny is here for you. Please contact your Progyny Care Advocate for support.
Disclaimer: The information provided by Progyny is for educational purposes only and is not medical advice. Always consult a qualified healthcare provider for medical guidance.